Activation of the central nervous system induced by micro-magnetic stimulation
نویسندگان
چکیده
Electrical and transcranial magnetic stimulations have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for investigating nervous system functions. Despite this success, these technologies have technical and practical limitations impeding the maximization of their full clinical and preclinical potential. Recently, micro-magnetic stimulation, which may offer advantages over electrical and transcranial magnetic stimulation, has proven effective in activating the neuronal circuitry of the retina in vitro. Here we demonstrate that this technology is also capable of activating neuronal circuitry on a systems level using an in vivo preparation. Specifically, the application of micro-magnetic fields to the dorsal cochlear nucleus activates inferior colliculus neurons. Additionally, we demonstrate the efficacy and characteristics of activation using different magnetic stimulation parameters. These findings provide a rationale for further exploration of micro-magnetic stimulation as a prospective tool for clinical and preclinical applications.
منابع مشابه
Non Invasive Brain Stimulation by Transcranial Magnetic Stimulation (TMS): Principles and Applications
Magnetic brain stimulation used as a method of psychological interventions in the treatment of diseases. This method functions used in the treatment of clinical disorder such as speech and movement disorders caused by stroke, tinnitus, Parkinson's disease, nervous tics. Applications in the field of psychological therapy, it is possible to stimulate specific brain area involved in certain mental...
متن کاملRepetitive transcranial magnetic stimulation in delirium: A double-blind, randomized, sham-controlled, pilot study
Purpose: Delirium is a fatal but potentially reversible disorder of Central Nervous System that adds a lot of costs on health systems. The aim of this study was to evaluate the effect of intermittent theta burst stimulation on severity and course of delirium. Methods: This was a double-blind, randomized, sham-controlled, pilot study. The participants were randomly allocated into two groups of ...
متن کاملP 64: Micro-Rna Disorder and Multiple Sclerosis
Noncoding ribonucleic acids micro-RNA is involved in the regulation of gene expression have major roles in the post-transcriptional level. A micro-RNA alone several causes down regulation of mRNA transcript of the target. Thus, small changes in the expression of a micro RNA may lead to significant changes in gene expression are different. Micro- RNA as key regulators of immune cell lineage diff...
متن کاملModulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells
Background: Microglial cells act as the sentinel of the central nervous system .They are involved in neuroprotection but are highly implicated in neurodegeneration of the aging brain. When over-activated, microglia release pro-inflammatory factors, such as nitric oxide (NO) and cytokines, which are critical in eliciting neuroinflammatory responses associated with neurodegenerative diseases. Thi...
متن کاملMagnetic Resonance Imaging of Central Nervous System and Paranasal Sinuses in Multiple Sclerosis Patients: Findings from a Survey of Clinical Records in Kermanshah Province
Background and Objectives: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system with more than 5.2 million people across the world being afflicted with. Magnetic Resonance Imaging (MRI) is a valuable tool in the diagnosis of MS. This study surveys the results of MRI of the central nervous system and paranasal sinuses in the sample of MS patients in Ker...
متن کامل